Hematocrit Interference Mechanisms and Correction Algorithms

Introduction

Hematocrit (Hct) interference distorts blood glucose readings by altering red blood cell (RBC) volume.

The Hct Effect

• High Hct blocks glucose diffusion, causing false lows.
• Low Hct accelerates diffusion, causing false highs.

Mitigating Hct Interference

Manufacturers employ AC Impedance Spectroscopy and Multi-Electrode designs to measure blood resistance and estimate RBC volume, complying with ISO 15197:2013.

Correction Algorithms

Developers apply mathematical corrections to results. Alternatively, lytic agents or filtration meshes remove RBCs from the reaction zone.

References

See citations below for further information on Hct interference mechanisms and correction algorithms.